Detalhe da pesquisa
1.
NRX-0492 degrades wild-type and C481 mutant BTK and demonstrates in vivo activity in CLL patient-derived xenografts.
Blood
; 141(13): 1584-1596, 2023 03 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-36375120
2.
Sphingosine-1-phosphate induces airway smooth muscle hyperresponsiveness and proliferation.
J Allergy Clin Immunol
; 152(5): 1131-1140.e6, 2023 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-37474025
3.
Inhibition of Janus kinase signaling during controlled mechanical ventilation prevents ventilation-induced diaphragm dysfunction.
FASEB J
; 28(7): 2790-803, 2014 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-24671708
4.
Kinase-impaired BTK mutations are susceptible to clinical-stage BTK and IKZF1/3 degrader NX-2127.
Science
; 383(6682): eadi5798, 2024 Feb 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-38301010
5.
Long-Standing Overt Ventriculomegaly in Adults: A Systematic Review and Meta-Analysis of Endoscopic Third Ventriculostomy Versus Ventriculoperitoneal Shunt as First-Line Treatment.
World Neurosurg
; 174: 213-220.e2, 2023 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-36958719
6.
Tamoxifen Therapy for Recurrent Mucosal Bleeding in Hereditary Hemorrhagic Telangiectasia.
J Hematol
; 10(1): 22-24, 2021 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-33643506
7.
Prospective discovery of small molecule enhancers of an E3 ligase-substrate interaction.
Nat Commun
; 10(1): 1402, 2019 03 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-30926793
8.
A class of small molecules that inhibit TNFalpha-induced survival and death pathways via prevention of interactions between TNFalphaRI, TRADD, and RIP1.
Chem Biol
; 14(10): 1105-18, 2007 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-17961823
9.
R-253 disrupts microtubule networks in multiple tumor cell lines.
Clin Cancer Res
; 12(12): 3831-42, 2006 Jun 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-16778111
10.
A potent and highly selective VPAC2 agonist enhances glucose-induced insulin release and glucose disposal: a potential therapy for type 2 diabetes.
Diabetes
; 51(5): 1453-60, 2002 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-11978642
11.
AMPK activation through mitochondrial regulation results in increased substrate oxidation and improved metabolic parameters in models of diabetes.
PLoS One
; 8(12): e81870, 2013.
Artigo
em Inglês
| MEDLINE | ID: mdl-24339975
12.
Guiding Framework for Driver Assessment Using Driving Simulators.
Front Psychol
; 8: 1428, 2017.
Artigo
em Inglês
| MEDLINE | ID: mdl-28878721
13.
Engineering novel VPAC2-selective agonists with improved stability and glucose-lowering activity in vivo.
J Pharmacol Exp Ther
; 320(2): 900-6, 2007 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-17110523
14.
Design of a long acting peptide functioning as both a glucagon-like peptide-1 receptor agonist and a glucagon receptor antagonist.
J Biol Chem
; 281(18): 12506-15, 2006 May 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-16505481
15.
Generation of highly selective VPAC2 receptor agonists by high throughput mutagenesis of vasoactive intestinal peptide and pituitary adenylate cyclase-activating peptide.
J Biol Chem
; 278(12): 10273-81, 2003 Mar 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-12525492